| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM50151347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306166 (CHEMBL830961) |
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| IC50 | >16000±n/a nM |
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| Citation |  Gellibert, F; Woolven, J; Fouchet, MH; Mathews, N; Goodland, H; Lovegrove, V; Laroze, A; Nguyen, VL; Sautet, S; Wang, R; Janson, C; Smith, W; Krysa, G; Boullay, V; De Gouville, AC; Huet, S; Hartley, D Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem47:4494-506 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM50151347 |
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| n/a |
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| Name | BDBM50151347 |
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| Synonyms: | 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine | 2-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-[1,5]naphthyridine | CHEMBL185238 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N5 |
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| Mol. Mass. | 287.3186 |
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| SMILES | Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1 |
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| Structure | 
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