| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sensory histidine kinase DcuS |
|---|
| Ligand | BDBM50151881 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305474 (CHEMBL831083) |
|---|
| IC50 | 8000±n/a nM |
|---|
| Citation |  Chan, WC; Coyle, BJ; Williams, P Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors. J Med Chem47:4633-41 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sensory histidine kinase DcuS |
|---|
| Name: | Sensory histidine kinase DcuS |
|---|
| Synonyms: | Receptor-histidine kinase AgrC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49890.25 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_305973 |
|---|
| Residue: | 430 |
|---|
| Sequence: | MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLI
ILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVV
YVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIR
QYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHD
YVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAK
ILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESE
NSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGF
FIQKVEIINN
|
|
|
|---|
| BDBM50151881 |
|---|
| n/a |
|---|
| Name | BDBM50151881 |
|---|
| Synonyms: | CHEMBL362839 | Cyclo(Ac-Cys-Asp-Phe-Ile-Met) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H41N5O8S2 |
|---|
| Mol. Mass. | 651.795 |
|---|
| SMILES | CC[C@H](C)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CSC(=O)[C@H](CCSC)NC1=O)NC(C)=O |
|---|
| Structure | 
|
|---|
Search and Browse
