| Reaction Details |
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 | Report a problem with these data |
| Target | Sensory histidine kinase DcuS |
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| Ligand | BDBM50151879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305974 (CHEMBL832960) |
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| IC50 | 6±n/a nM |
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| Citation |  Chan, WC; Coyle, BJ; Williams, P Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors. J Med Chem47:4633-41 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sensory histidine kinase DcuS |
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| Name: | Sensory histidine kinase DcuS |
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| Synonyms: | Receptor-histidine kinase AgrC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49890.25 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_305973 |
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| Residue: | 430 |
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| Sequence: | MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLI
ILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVV
YVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIR
QYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHD
YVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAK
ILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESE
NSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGF
FIQKVEIINN
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| BDBM50151879 |
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| n/a |
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| Name | BDBM50151879 |
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| Synonyms: | 2-{2-[2-(2-{2-[2-(2-Amino-3-methyl-pentanoylamino)-3-carbamoyl-propionylamino]-3-mercapto-propionylamino}-3-carboxy-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid | CHEMBL360749 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H60N8O11S |
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| Mol. Mass. | 836.995 |
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| SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O |
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| Structure | 
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