| Reaction Details |
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 | Report a problem with these data |
| Target | Sensory histidine kinase DcuS |
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| Ligand | BDBM50151882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304243 (CHEMBL841798) |
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| EC50 | 11000±n/a nM |
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| Citation |  Chan, WC; Coyle, BJ; Williams, P Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors. J Med Chem47:4633-41 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sensory histidine kinase DcuS |
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| Name: | Sensory histidine kinase DcuS |
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| Synonyms: | Receptor-histidine kinase AgrC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49890.25 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_305973 |
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| Residue: | 430 |
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| Sequence: | MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLI
ILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVV
YVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIR
QYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHD
YVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAK
ILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESE
NSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGF
FIQKVEIINN
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| BDBM50151882 |
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| n/a |
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| Name | BDBM50151882 |
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| Synonyms: | CHEMBL425533 | [15-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-3-hydroxy-butyrylamino)-9-benzyl-6-sec-butyl-3-methyl-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetraaza-cyclohexadec-12-yl]-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C41H56N8O13S |
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| Mol. Mass. | 900.994 |
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| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSC(=O)[C@@H](C)NC1=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O |
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| Structure | 
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