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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50152165 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 9.4±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50152165 | |||
| n/a | |||
| Name | BDBM50152165 | ||
| Synonyms: | CHEMBL186992 | [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-(1-ethyl-propyl)-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H30N6 | ||
| Mol. Mass. | 366.5031 | ||
| SMILES | CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.49,3.73,;4.99,4.06,;3.97,2.89,;2.46,3.21,;1.97,4.67,;4.44,1.42,;3.43,.28,;3.9,-1.17,;2.88,-2.32,;3.37,-3.78,;1.38,-2.01,;.89,-.56,;-.51,.07,;-.35,1.61,;-1.51,2.61,;1.15,1.94,;1.92,.6,;-1.84,-.71,;-1.84,-2.25,;-3.17,-3.02,;-4.5,-2.25,;-4.5,-.71,;-3.17,.07,;-3.17,1.61,;-5.83,-3.02,;-7.18,-2.25,;-5.83,-4.56,)| | ||
| Structure | 
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