Ki Summary

Reaction Details

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Target

Tryptase beta-2

Ligand

BDBM50152198

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303103 (CHEMBL829613)

138±n/a nM

Citation

Hopkins, C; Neuenschwander, K; Scotese, A; Jackson, S; Nieduzak, T; Pauls, H; Liang, G; Sides, K; Cramer, D; Cairns, J; Maignan, S; Mathieu, M Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. Bioorg Med Chem Lett14:4819-23 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tryptase beta-2

Name:

Tryptase beta-2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

30518.79

Organism:

Homo sapiens (Human)

Description:

ChEMBL_210702

Residue:

275

Sequence:

MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP

BDBM50152198

n/a

Name

BDBM50152198

Synonyms:

2-[3-(4-Amino-cyclohexylamino)-5-chloro-6-methyl-2-oxo-2H-pyrazin-1-yl]-N-(3-aminomethyl-phenyl)-acetamide; TFA | CHEMBL184499

Type

Small organic molecule

Emp. Form.

C20H27ClN6O2

Mol. Mass.

418.92

SMILES

Cc1c(Cl)nc(NC2CC[C@H](N)CC2)c(=O)n1CC(=O)Nc1cccc(CN)c1 |wU:10.10,(.97,.46,;-.37,-.31,;-1.7,.46,;-1.72,2,;-3.03,-.31,;-3.03,-1.86,;-4.39,-2.63,;-5.72,-1.86,;-5.7,-.31,;-7.03,.46,;-8.36,-.31,;-9.72,.46,;-8.39,-1.86,;-7.05,-2.63,;-1.7,-2.63,;-1.7,-4.17,;-.37,-1.86,;.97,-2.63,;2.3,-1.86,;2.3,-.31,;3.66,-2.63,;4.99,-1.86,;4.96,-.31,;6.3,.46,;7.65,-.31,;7.65,-1.86,;8.99,-2.63,;10.32,-1.86,;6.32,-2.63,)|

Structure