| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptase beta-2 |
|---|
| Ligand | BDBM16127 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_303103 (CHEMBL829613) |
|---|
| Ki | 140±n/a nM |
|---|
| Citation |  Hopkins, C; Neuenschwander, K; Scotese, A; Jackson, S; Nieduzak, T; Pauls, H; Liang, G; Sides, K; Cramer, D; Cairns, J; Maignan, S; Mathieu, M Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. Bioorg Med Chem Lett14:4819-23 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptase beta-2 |
|---|
| Name: | Tryptase beta-2 |
|---|
| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30518.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_210702 |
|---|
| Residue: | 275 |
|---|
| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
|
|
|
|---|
| BDBM16127 |
|---|
| n/a |
|---|
| Name | BDBM16127 |
|---|
| Synonyms: | 2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide) | 2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide | AIDS007118 | BABIM | CHEMBL542712 | CHEMBL99951 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16N8 |
|---|
| Mol. Mass. | 332.3625 |
|---|
| SMILES | NC(=N)c1ccc2nc(Cc3nc4ccc(cc4[nH]3)C(N)=N)[nH]c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
