| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptase beta-2 |
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| Ligand | BDBM50152203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303103 (CHEMBL829613) |
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| Ki | 615.0±n/a nM |
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| Citation |  Hopkins, C; Neuenschwander, K; Scotese, A; Jackson, S; Nieduzak, T; Pauls, H; Liang, G; Sides, K; Cramer, D; Cairns, J; Maignan, S; Mathieu, M Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. Bioorg Med Chem Lett14:4819-23 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptase beta-2 |
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| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| BDBM50152203 |
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| n/a |
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| Name | BDBM50152203 |
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| Synonyms: | 2-[3-(4-Aminomethyl-benzylamino)-5-chloro-6-methyl-2-oxo-2H-pyrazin-1-yl]-N-(3-aminomethyl-phenyl)-acetamide; TFA | CHEMBL185008 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25ClN6O2 |
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| Mol. Mass. | 440.926 |
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| SMILES | Cc1c(Cl)nc(NCc2ccc(CN)cc2)c(=O)n1CC(=O)Nc1cccc(CN)c1 |
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| Structure | 
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