| Reaction Details |
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 | Report a problem with these data |
| Target | Flap endonuclease 1 |
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| Ligand | BDBM50083940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304758 (CHEMBL829355) |
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| IC50 | 6960±n/a nM |
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| Citation |  Tumey, LN; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Bailey, A; Dent, T; Leventhal, C; Harrington, J; Bennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett14:4915-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Flap endonuclease 1 |
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| Name: | Flap endonuclease 1 |
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| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42602.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517026 |
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| Residue: | 380 |
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| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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| BDBM50083940 |
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| n/a |
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| Name | BDBM50083940 |
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| Synonyms: | 4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.2H2O) | CHEMBL184215 | CHEMBL278763 | Sacchettini_6 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H7ClO4 |
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| Mol. Mass. | 226.613 |
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| SMILES | OC(=O)C(=O)CC(=O)c1cccc(Cl)c1 |
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| Structure | 
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