| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA excision repair protein ERCC-5 |
|---|
| Ligand | BDBM50152572 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304836 (CHEMBL827924) |
|---|
| IC50 | 1850±n/a nM |
|---|
| Citation |  Tumey, LN; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Bailey, A; Dent, T; Leventhal, C; Harrington, J; Bennani, YL The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors. Bioorg Med Chem Lett14:4915-8 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA excision repair protein ERCC-5 |
|---|
| Name: | DNA excision repair protein ERCC-5 |
|---|
| Synonyms: | ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 133069.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_305129 |
|---|
| Residue: | 1186 |
|---|
| Sequence: | MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
|
|
|
|---|
| BDBM50152572 |
|---|
| n/a |
|---|
| Name | BDBM50152572 |
|---|
| Synonyms: | 2,4-Dioxo-4-(5-phenyl-thiophen-2-yl)-butyric acid | CHEMBL182485 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10O4S |
|---|
| Mol. Mass. | 274.292 |
|---|
| SMILES | OC(=O)C(=O)CC(=O)c1ccc(s1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
