| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-2 |
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| Ligand | BDBM50583520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2157590 (CHEMBL5042250) |
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| IC50 | 1650±n/a nM |
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| Citation |  M Serafim, RA; da Silva Santiago, A; Schwalm, MP; Hu, Z; Dos Reis, CV; Takarada, JE; Mezzomo, P; Massirer, KB; Kudolo, M; Gerstenecker, S; Chaikuad, A; Zender, L; Knapp, S; Laufer, S; Couņago, RM; Gehringer, M Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem65:3173-3192 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-2 |
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| Name: | Ribosomal protein S6 kinase beta-2 |
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| Synonyms: | KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53460.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306115 |
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| Residue: | 482 |
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| Sequence: | MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
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| BDBM50583520 |
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| n/a |
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| Name | BDBM50583520 |
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| Synonyms: | CHEMBL5094006 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H40N8O2 |
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| Mol. Mass. | 604.7445 |
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| SMILES | CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)nc-21 |
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| Structure | 
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