Reaction Details |
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Target | Cyclin-H/Cyclin-dependent kinase 7 |
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Ligand | BDBM50583927 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2158414 (CHEMBL5043164) |
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Kd | 0.030000±n/a nM |
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Citation | Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. J Med Chem65:1458-1480 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-H/Cyclin-dependent kinase 7 |
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Name: | Cyclin-H/Cyclin-dependent kinase 7 |
Synonyms: | CDK-activating kinase assembly factor MAT1/Cyclin H/Cyclin-dependent kinase 7 | CDK7/Cyclin H | CDK7/H | Cyclin H/dependent kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7/ cyclin H | Cyclin-dependent kinase 7/cyclin H |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-H |
Synonyms: | CCNH | CCNH_HUMAN | Cyclin H | MO15-associated protein | p34 | p37 |
Type: | Enzyme Subunit |
Mol. Mass.: | 37646.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 323 |
Sequence: | MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
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Component 2 |
Name: | Cyclin-dependent kinase 7 |
Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
Type: | Enzyme Subunit |
Mol. Mass.: | 39047.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 346 |
Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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BDBM50583927 |
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n/a |
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Name | BDBM50583927 |
Synonyms: | CHEMBL5088381 |
Type | Small organic molecule |
Emp. Form. | C22H23ClF3N7O |
Mol. Mass. | 493.913 |
SMILES | Cl.Cc1noc(C)c1-c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F |r| |
Structure |
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