| Reaction Details |
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 | Report a problem with these data |
| Target | DCN1-like protein 1 |
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| Ligand | BDBM50584183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2159061 (CHEMBL5043811) |
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| IC50 | 21±n/a nM |
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| Citation |  He, ZX; An, Q; Wei, B; Zhou, WJ; Wei, BF; Gong, YP; Zhang, X; Gao, G; Dong, GJ; Huo, JL; Zhang, XH; Yang, FF; Liu, HM; Ma, LY; Zhao, W Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem65:163-190 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DCN1-like protein 1 |
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| Name: | DCN1-like protein 1 |
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| Synonyms: | DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30118.96 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117443 |
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| Residue: | 259 |
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| Sequence: | MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL
DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ
EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA
YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI
DDFVEFARPQIAGTKSTTV
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| BDBM50584183 |
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| n/a |
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| Name | BDBM50584183 |
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| Synonyms: | CHEMBL5089944 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N4S3 |
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| Mol. Mass. | 446.611 |
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| SMILES | Cc1ccc(CSc2nc(Sc3nccs3)c(C#N)c(n2)-c2ccc(C)cc2)cc1 |
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| Structure | 
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