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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Growth hormone secretagogue receptor type 1 | ||
| Ligand | BDBM50153546 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306821 (CHEMBL831012) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Liu, B; Liu, G; Xin, Z; Serby, MD; Zhao, H; Schaefer, VG; Falls, HD; Kaszubska, W; Collins, CA; Sham, HL Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists. Bioorg Med Chem Lett14:5223-6 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Growth hormone secretagogue receptor type 1 | |||
| Name: | Growth hormone secretagogue receptor type 1 | ||
| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) | ||
| Type: | Receptor | ||
| Mol. Mass.: | 41334.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. | ||
| Residue: | 366 | ||
| Sequence: |
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| BDBM50153546 | |||
| n/a | |||
| Name | BDBM50153546 | ||
| Synonyms: | 3-(2,6-Dichloro-phenyl)-5-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide | CHEMBL185057 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28Cl2N4O3 | ||
| Mol. Mass. | 515.432 | ||
| SMILES | CCN(CC)c1ccc(NC(=O)c2c(CCN3CCCC3=O)onc2-c2c(Cl)cccc2Cl)cc1 |(8.03,-3.46,;6.56,-2.99,;6.23,-1.5,;7.38,-.45,;8.85,-.92,;4.77,-1.01,;3.62,-2.06,;2.18,-1.57,;1.85,-.08,;.38,.39,;-.75,-.64,;-.44,-2.13,;-2.23,-.17,;-2.7,1.3,;-1.81,2.54,;-2.43,3.96,;-1.53,5.19,;,5.19,;.47,6.66,;-.79,7.54,;-2.02,6.66,;-3.49,7.13,;-4.24,1.3,;-4.73,-.17,;-3.47,-1.06,;-3.47,-2.6,;-4.8,-3.39,;-6.13,-2.6,;-4.8,-4.92,;-3.47,-5.7,;-2.11,-4.92,;-2.11,-3.37,;-.58,-3.37,;2.99,.95,;4.44,.49,)| | ||
| Structure | 
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