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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ephrin type-A receptor 1 | ||
| Ligand | BDBM50584948 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2160972 (CHEMBL5045722) | ||
| IC50 | 303±n/a nM | ||
| Citation |  Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem65:3229-3248 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ephrin type-A receptor 1 | |||
| Name: | Ephrin type-A receptor 1 | ||
| Synonyms: | EPH | EPH tyrosine kinase | EPH tyrosine kinase 1 | EPHA1 | EPHA1_HUMAN | EPHT | EPHT1 | Ephrin receptor | Ephrin type-A receptor 1 | Ephrin type-A receptor 1 (EPHA1) | Erythropoietin-producing hepatoma receptor | Tyrosine-protein kinase receptor EPH | hEpha1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 108128.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21709 | ||
| Residue: | 976 | ||
| Sequence: |
| ||
| BDBM50584948 | |||
| n/a | |||
| Name | BDBM50584948 | ||
| Synonyms: | CHEMBL5092606 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25F3N6O | ||
| Mol. Mass. | 422.4473 | ||
| SMILES | CN(C)C(=O)c1ccc(Nc2ncc(c(N[C@@H]3CC[C@H](N)CC3)n2)C(F)(F)F)cc1 |r,wU:16.15,19.19,(85.12,-20.14,;83.79,-20.91,;83.79,-22.45,;82.45,-20.15,;82.45,-18.61,;81.12,-20.92,;81.12,-22.46,;79.79,-23.23,;78.46,-22.46,;77.13,-23.24,;75.79,-22.47,;74.46,-23.24,;73.12,-22.47,;73.12,-20.92,;74.45,-20.15,;74.45,-18.61,;75.78,-17.84,;77.11,-18.61,;78.44,-17.84,;78.44,-16.3,;79.78,-15.53,;77.11,-15.53,;75.77,-16.3,;75.79,-20.92,;71.79,-20.15,;71.79,-18.61,;70.46,-20.93,;70.45,-19.38,;78.45,-20.93,;79.78,-20.15,)| | ||
| Structure | 
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