| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50153926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305948 (CHEMBL832788) |
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| IC50 | 7400±n/a nM |
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| Citation |  Imai, M; Shiota, T; Kataoka, K; Tarby, CM; Moree, WJ; Tsutsumi, T; Sudo, M; Ramirez-Weinhouse, MM; Comer, D; Sun, CM; Yamagami, S; Tanaka, H; Morita, T; Hada, T; Greene, J; Barnum, D; Saunders, J; Myers, PL; Kato, Y; Endo, N Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. Bioorg Med Chem Lett14:5407-11 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50153926 |
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| n/a |
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| Name | BDBM50153926 |
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| Synonyms: | 4-Methyl-thiophene-2-carboxylic acid N''-{2-[4-(4-chloro-benzyl)-[1,4]diazepan-1-yl]-acetyl}-hydrazide | CHEMBL186855 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25ClN4O2S |
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| Mol. Mass. | 420.956 |
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| SMILES | Cc1csc(c1)C(=O)NNC(=O)CN1CCCN(Cc2ccc(Cl)cc2)CC1 |
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| Structure | 
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