| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50236430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_310494 (CHEMBL834068) |
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| EC50 | 20±n/a nM |
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| Citation |  Moree, WJ; Kataoka, K; Ramirez-Weinhouse, MM; Shiota, T; Imai, M; Sudo, M; Tsutsumi, T; Endo, N; Muroga, Y; Hada, T; Tanaka, H; Morita, T; Greene, J; Barnum, D; Saunders, J; Kato, Y; Myers, PL; Tarby, CM Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett14:5413-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50236430 |
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| n/a |
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| Name | BDBM50236430 |
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| Synonyms: | (R)-N-(2-(1-(4-chlorobenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide | CHEMBL255408 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClF3N3O2 |
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| Mol. Mass. | 439.859 |
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| SMILES | FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 |
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| Structure | 
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