| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50154140 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306447 (CHEMBL829091) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Malamas, MS; Manas, ES; McDevitt, RE; Gunawan, I; Xu, ZB; Collini, MD; Miller, CP; Dinh, T; Henderson, RA; Keith, JC; Harris, HA Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem47:5021-40 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM50154140 |
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| n/a |
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| Name | BDBM50154140 |
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| Synonyms: | 2-(2-Fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol | 2-(2-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | 2-(3-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | CHEMBL188846 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10FNO3 |
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| Mol. Mass. | 271.2432 |
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| SMILES | Oc1ccc(-c2nc3cc(O)cc(C=C)c3o2)c(F)c1 |
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| Structure | 
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