| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP/microtubule affinity-regulating kinase 4 |
|---|
| Ligand | BDBM50516171 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2161727 (CHEMBL5046588) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem65:1313-1328 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP/microtubule affinity-regulating kinase 4 |
|---|
| Name: | MAP/microtubule affinity-regulating kinase 4 |
|---|
| Synonyms: | KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 82561.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774620 |
|---|
| Residue: | 752 |
|---|
| Sequence: | MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPW
SVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLP
RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
|
|
|
|---|
| BDBM50516171 |
|---|
| n/a |
|---|
| Name | BDBM50516171 |
|---|
| Synonyms: | CHEMBL4446892 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17BrF3N7O2S |
|---|
| Mol. Mass. | 520.327 |
|---|
| SMILES | Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
