| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase ULK3 |
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| Ligand | BDBM50585187 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161745 (CHEMBL5046606) |
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| IC50 | 343±n/a nM |
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| Citation |  Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem65:1313-1328 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase ULK3 |
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| Name: | Serine/threonine-protein kinase ULK3 |
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| Synonyms: | ULK3 | ULK3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53449.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774298 |
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| Residue: | 472 |
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| Sequence: | MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL
TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ
LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM
APEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLS
RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDS
AAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGT
SARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPG
RRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
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| BDBM50585187 |
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| n/a |
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| Name | BDBM50585187 |
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| Synonyms: | CHEMBL5079601 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28F3N7O |
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| Mol. Mass. | 451.4885 |
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| SMILES | Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCCCNC(=O)C2CCC2)n1 |
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| Structure | 
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