| Reaction Details |
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 | Report a problem with these data |
| Target | NUAK family SNF1-like kinase 1 |
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| Ligand | BDBM50585191 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161765 (CHEMBL5046626) |
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| IC50 | >10000±n/a nM |
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| Citation |  Drewry, DH; Annor-Gyamfi, JK; Wells, CI; Pickett, JE; Dederer, V; Preuss, F; Mathea, S; Axtman, AD Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem65:1313-1328 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NUAK family SNF1-like kinase 1 |
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| Name: | NUAK family SNF1-like kinase 1 |
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| Synonyms: | ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74326.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451343 |
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| Residue: | 661 |
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| Sequence: | MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
N
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| BDBM50585191 |
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| n/a |
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| Name | BDBM50585191 |
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| Synonyms: | CHEMBL5079149 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24BrN7O3S |
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| Mol. Mass. | 546.44 |
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| SMILES | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 |
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| Structure | 
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