Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50586119 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2164694 (CHEMBL5049555) |
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Ki | 0.590000±n/a nM |
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Citation | Pagare, PP; Li, M; Zheng, Y; Kulkarni, AS; Obeng, S; Huang, B; Ruiz, C; Gillespie, JC; Mendez, RE; Stevens, DL; Poklis, JL; Halquist, MS; Dewey, WL; Selley, DE; Zhang, Y Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. J Med Chem65:5095-5112 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44431.62 |
Organism: | MOUSE |
Description: | OPIATE Mu OPRM1 MOUSE::P42866 |
Residue: | 398 |
Sequence: | MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50586119 |
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n/a |
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Name | BDBM50586119 |
Synonyms: | CHEMBL5083572 |
Type | Small organic molecule |
Emp. Form. | C26H31ClN2O5 |
Mol. Mass. | 486.988 |
SMILES | Cl.[H][C@@]12Oc3c4c(C[C@H]5N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@@H]2NC(=O)Cc1ccco1)ccc3O |r,THB:10:9:17:6.5.7| |
Structure |
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