| Reaction Details |
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 | Report a problem with these data |
| Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Ligand | BDBM50586277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2165791 (CHEMBL5050652) |
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| IC50 | 50±n/a nM |
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| Citation |  Shi, R; Wang, B; Stelitano, G; Wu, X; Shan, Y; Wu, Y; Wang, X; Chiarelli, LR; Lu, Y; Qiao, C Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents. ACS Med Chem Lett13:593-598 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50167.60 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116793 |
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| Residue: | 461 |
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| Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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| BDBM50586277 |
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| n/a |
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| Name | BDBM50586277 |
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| Synonyms: | CHEMBL4868912 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O5S2 |
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| Mol. Mass. | 466.574 |
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| SMILES | CS(=O)(=O)c1cc([N+]([O-])=O)c2sc(nc(=O)c2c1)N1CCN(CC2CCCCC2)CC1 |
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| Structure | 
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