| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50586343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2165963 (CHEMBL5050824) |
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| EC50 | <6.1±n/a nM |
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| Citation |  Kargbo, RB Small-Molecule Inhibitor of the Oncogenic KRAS ACS Med Chem Lett13:767-769 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50586343 |
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| n/a |
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| Name | BDBM50586343 |
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| Synonyms: | CHEMBL5074707 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41N5O3 |
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| Mol. Mass. | 555.7103 |
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| SMILES | C[C@@H]1Cc2c(C[C@H]1c1cc(O)cc3ccccc13)nc(OC[C@@H]1CCCN1C)nc2N1CCN(C[C@@H]1C)C(=O)C=C |r| |
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| Structure | 
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