Reaction Details |
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Target | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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Ligand | BDBM50586355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2168504 (CHEMBL5053563) |
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IC50 | 700±n/a nM |
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Citation | Whitfield, H; Hemmings, AM; Mills, SJ; Baker, K; White, G; Rushworth, S; Riley, AM; Potter, BVL; Brearley, CA Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention. J Med Chem64:3813-3826 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
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Name: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 |
Synonyms: | INPPL-1 | INPPL1 | Inositol polyphosphate phosphatase-like protein 1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Protein 51C | SH2 domain-containing inositol phosphatase 2 | SHIP-2 | SHIP2 | SHIP2_HUMAN | Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) |
Type: | Enzyme |
Mol. Mass.: | 138596.65 |
Organism: | Homo sapiens (Human) |
Description: | O15357 |
Residue: | 1258 |
Sequence: | MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
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BDBM50586355 |
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n/a |
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Name | BDBM50586355 |
Synonyms: | CHEMBL5087243 |
Type | Small organic molecule |
Emp. Form. | C12H16O24P6 |
Mol. Mass. | 730.0836 |
SMILES | OP(O)(=O)Oc1cc(cc(OP(O)(O)=O)c1OP(O)(O)=O)-c1cc(OP(O)(O)=O)c(OP(O)(O)=O)c(OP(O)(O)=O)c1 |
Structure |
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