| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid hormone receptor ERR1 |
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| Ligand | BDBM50155830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305523 (CHEMBL827660) |
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| IC50 | 920±n/a nM |
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| Citation |  Busch, BB; Stevens, WC; Martin, R; Ordentlich, P; Zhou, S; Sapp, DW; Horlick, RA; Mohan, R Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem47:5593-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid hormone receptor ERR1 |
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| Name: | Steroid hormone receptor ERR1 |
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| Synonyms: | ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45508.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1499891 |
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| Residue: | 423 |
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| Sequence: | MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAG
PGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE
CEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGP
LAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTI
SWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAA
GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALL
EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEA
MMD
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| BDBM50155830 |
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| n/a |
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| Name | BDBM50155830 |
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| Synonyms: | 2-Cyano-N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-3-[4-(4-fluoro-2-trifluoromethyl-benzyloxy)-3-methoxy-phenyl]-acrylamide | CHEMBL361308 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18F4N4O3S |
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| Mol. Mass. | 506.473 |
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| SMILES | CCc1nnc(NC(=O)C(=C\c2ccc(OCc3ccc(F)cc3C(F)(F)F)c(OC)c2)\C#N)s1 |
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| Structure | 
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