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TargetNuclear receptor ROR-gamma
LigandBDBM302860
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2168563 (CHEMBL5053622)
Ki 17±n/a nM
Citation Lugar, CWClarke, CAMorphy, RRudyk, HSapmaz, SStites, REVaught, GMFurness, KBroughton, HBDurst, GLClawson, DKStout, SLGuo, SYDurbin, JDStayrook, KREdmondson, DDKikly, KNew, NEBina, HAChambers, MGShetler, PChang, WYChang, VCBarr, RGough, WHSteele, JPGetman, BPatel, NMathes, BMRichardson, TI Defining Target Engagement Required for Efficacy  J Med Chem64:5470-5484 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Enzyme Catalytic Domain
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM302860
n/a
NameBDBM302860
Synonyms:(2S)-1-(3-Thienyl)propan-2-ol | US9598431, 3
TypeSmall organic molecule
Emp. Form.C28H32F3N5O4S2
Mol. Mass.623.71
SMILESCCS(=O)(=O)c1ccc(CNC(=O)c2cc3C[C@H](C)OC4(CCN(CC4)[C@H](C)c4cnc(nc4)C(F)(F)F)c3s2)nc1 |r|
Structure
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