| Reaction Details |
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 | Report a problem with these data |
| Target | N6-adenosine-methyltransferase catalytic subunit |
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| Ligand | BDBM50586482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2168906 (CHEMBL5053965) |
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| IC50 | 5800±n/a nM |
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| Citation |  Dolbois, A; Bedi, RK; Bochenkova, E; Müller, A; Moroz-Omori, EV; Huang, D; Caflisch, A 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J Med Chem64:12738-12760 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N6-adenosine-methyltransferase catalytic subunit |
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| Name: | N6-adenosine-methyltransferase catalytic subunit |
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| Synonyms: | 2.1.1.348 | METTL3 | MT-A70 | MTA70 | MTA70_HUMAN | Methyltransferase-like protein 3 | N6-adenosine-methyltransferase 70 kDa subunit | N6-adenosine-methyltransferase catalytic subunit | hMETTL3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64471.71 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120160 |
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| Residue: | 580 |
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| Sequence: | MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGG
PKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLL
QKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRA
EQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSK
KVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFR
RIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVG
GDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIP
VLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGK
EHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNV
QPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
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| BDBM50586482 |
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| n/a |
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| Name | BDBM50586482 |
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| Synonyms: | CHEMBL5078612 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H37N7O |
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| Mol. Mass. | 439.5969 |
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| SMILES | CNc1cc(ncn1)N1CCC(O)(CNc2ccc(CN3CCC(C)(C)CC3)nc2)CC1 |
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| Structure | 
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