Reaction Details |
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Target | N6-adenosine-methyltransferase catalytic subunit |
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Ligand | BDBM50586490 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2168906 (CHEMBL5053965) |
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IC50 | 1800±n/a nM |
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Citation | Dolbois, A; Bedi, RK; Bochenkova, E; Müller, A; Moroz-Omori, EV; Huang, D; Caflisch, A 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J Med Chem64:12738-12760 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N6-adenosine-methyltransferase catalytic subunit |
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Name: | N6-adenosine-methyltransferase catalytic subunit |
Synonyms: | 2.1.1.348 | METTL3 | MT-A70 | MTA70 | MTA70_HUMAN | Methyltransferase-like protein 3 | N6-adenosine-methyltransferase 70 kDa subunit | N6-adenosine-methyltransferase catalytic subunit | hMETTL3 |
Type: | PROTEIN |
Mol. Mass.: | 64471.71 |
Organism: | Homo sapiens |
Description: | ChEMBL_120160 |
Residue: | 580 |
Sequence: | MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGG
PKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLL
QKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRA
EQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSK
KVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFR
RIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVG
GDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIP
VLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGK
EHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNV
QPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
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BDBM50586490 |
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n/a |
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Name | BDBM50586490 |
Synonyms: | CHEMBL5083959 |
Type | Small organic molecule |
Emp. Form. | C26H37N7O |
Mol. Mass. | 463.6183 |
SMILES | CNc1cc(ncn1)N1CCC2(CN(C(=O)N2)c2ccc(CN3CCC(C)(C)CC3)cc2)CC1 |
Structure |
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