| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM50586865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2170067 (CHEMBL5055126) |
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| IC50 | 4.7±n/a nM |
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| Citation |  Wang, SP; Li, Y; Huang, SH; Wu, SQ; Gao, LL; Sun, Q; Lin, QW; Huang, L; Meng, LQ; Zou, Y; Zhu, QH; Xu, YG Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer. J Med Chem64:17413-17435 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 66225.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGN5 |
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| Residue: | 583 |
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| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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| BDBM50586865 |
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| n/a |
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| Name | BDBM50586865 |
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| Synonyms: | CHEMBL5084388 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N8O3 |
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| Mol. Mass. | 554.6428 |
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| SMILES | CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)N(C)c1ccc(cc1OC)-c1nc2c(cccc2[nH]1)C(N)=O |r| |
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| Structure | 
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