| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
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| Ligand | BDBM50586865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2170073 (CHEMBL5055132) |
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| IC50 | 123±n/a nM |
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| Citation |  Wang, SP; Li, Y; Huang, SH; Wu, SQ; Gao, LL; Sun, Q; Lin, QW; Huang, L; Meng, LQ; Zou, Y; Zhu, QH; Xu, YG Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer. J Med Chem64:17413-17435 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 3 |
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| Name: | Bromodomain-containing protein 3 |
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| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
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| Type: | Protein |
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| Mol. Mass.: | 79571.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15059 |
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| Residue: | 726 |
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| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
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| BDBM50586865 |
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| n/a |
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| Name | BDBM50586865 |
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| Synonyms: | CHEMBL5084388 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N8O3 |
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| Mol. Mass. | 554.6428 |
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| SMILES | CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)N(C)c1ccc(cc1OC)-c1nc2c(cccc2[nH]1)C(N)=O |r| |
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| Structure | 
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