| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50156978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306021 (CHEMBL833536) |
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| IC50 | 400±n/a nM |
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| Citation |  Burrows, JN; Cumming, JG; Fillery, SM; Hamlin, GA; Hudson, JA; Jackson, RJ; McLaughlin, S; Shaw, JS Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas. Bioorg Med Chem Lett15:25-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50156978 |
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| n/a |
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| Name | BDBM50156978 |
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| Synonyms: | 2-(4-Dimethylsulfamoyl-phenyl)-N-[1-(3,3-diphenyl-propyl)-piperidin-4-yl]-N-ethyl-acetamide | CHEMBL179993 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N3O3S |
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| Mol. Mass. | 547.751 |
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| SMILES | CCN(C1CCN(CCC(c2ccccc2)c2ccccc2)CC1)C(=O)Cc1ccc(cc1)S(=O)(=O)N(C)C |
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| Structure | 
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