| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50157022 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306744 (CHEMBL830074) |
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| IC50 | 6100±n/a nM |
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| Citation |  Burrows, JN; Cumming, JG; Fillery, SM; Hamlin, GA; Hudson, JA; Jackson, RJ; McLaughlin, S; Shaw, JS Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas. Bioorg Med Chem Lett15:25-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50157022 |
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| n/a |
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| Name | BDBM50157022 |
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| Synonyms: | CHEMBL182266 | N-[1-(3,3-Diphenyl-propyl)-piperidin-4-yl]-N-methyl-isonicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N3O |
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| Mol. Mass. | 413.5545 |
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| SMILES | CN(C1CCN(CCC(c2ccccc2)c2ccccc2)CC1)C(=O)c1ccncc1 |
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| Structure | 
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