| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50157082 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302869 (CHEMBL876364) |
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| Ki | 34564.0±n/a nM |
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| Citation |  Bruncko, M; McClellan, WJ; Wendt, MD; Sauer, DR; Geyer, A; Dalton, CR; Kaminski, MA; Weitzberg, M; Gong, J; Dellaria, JF; Mantei, R; Zhao, X; Nienaber, VL; Stewart, K; Klinghofer, V; Bouska, J; Rockway, TW; Giranda, VL Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett15:93-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50157082 |
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| n/a |
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| Name | BDBM50157082 |
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| Synonyms: | 6-Styryl-naphthalene-2-carboxamidine | CHEMBL185345 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N2 |
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| Mol. Mass. | 272.3437 |
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| SMILES | NC(=N)c1ccc2cc(\C=C\c3ccccc3)ccc2c1 |
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| Structure | 
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