Reaction Details |
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Target | C5a anaphylatoxin chemotactic receptor 1 |
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Ligand | BDBM50587358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2172510 (CHEMBL5057644) |
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EC50 | 73±n/a nM |
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Citation | Gorman, DM; Li, XX; Lee, JD; Fung, JN; Cui, CS; Lee, HS; Rolfe, BE; Woodruff, TM; Clark, RJ Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. J Med Chem64:16598-16608 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C5a anaphylatoxin chemotactic receptor 1 |
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Name: | C5a anaphylatoxin chemotactic receptor 1 |
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 |
Type: | Enzyme |
Mol. Mass.: | 39347.68 |
Organism: | Homo sapiens (Human) |
Description: | P21730 |
Residue: | 350 |
Sequence: | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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BDBM50587358 |
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n/a |
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Name | BDBM50587358 |
Synonyms: | CHEMBL5085743 |
Type | Small organic molecule |
Emp. Form. | C49H74N12O10 |
Mol. Mass. | 991.1863 |
SMILES | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| |
Structure |
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