| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50149467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430085 (CHEMBL918106) |
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| IC50 | 1±n/a nM |
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| Citation |  Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. J Med Chem47:6556-68 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM50149467 |
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| n/a |
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| Name | BDBM50149467 |
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| Synonyms: | (5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,1-b][1,3]thiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium | CHEMBL122450 | Sodium; (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate | sodium (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10N3O3S2 |
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| Mol. Mass. | 344.389 |
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| SMILES | [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c3CCCc3sc2n1 |t:3| |
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| Structure | 
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