Reaction Details |
| Report a problem with these data |
Target | DNA excision repair protein ERCC-5 |
---|
Ligand | BDBM50157850 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_305129 (CHEMBL832425) |
---|
IC50 | 2±n/a nM |
---|
Citation | Tumey, LN; Bom, D; Huck, B; Gleason, E; Wang, J; Silver, D; Brunden, K; Boozer, S; Rundlett, S; Sherf, B; Murphy, S; Dent, T; Leventhal, C; Bailey, A; Harrington, J; Bennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett15:277-81 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA excision repair protein ERCC-5 |
---|
Name: | DNA excision repair protein ERCC-5 |
Synonyms: | ERCC5 | ERCC5_HUMAN | ERCM2 | XPG | XPGC |
Type: | PROTEIN |
Mol. Mass.: | 133069.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_305129 |
Residue: | 1186 |
Sequence: | MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
|
|
|
BDBM50157850 |
---|
n/a |
---|
Name | BDBM50157850 |
Synonyms: | 3-Hydroxy-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL182974 |
Type | Small organic molecule |
Emp. Form. | C13H10N2O3S |
Mol. Mass. | 274.295 |
SMILES | On1c(=O)n(Cc2ccccc2)c2sccc2c1=O |
Structure |
|