Reaction Details |
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Target | Reduced folate transporter |
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Ligand | BDBM50158570 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_430664 (CHEMBL919632) |
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Ki | 530±n/a nM |
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Citation | Rosowsky, A; Forsch, RA; Wright, JE Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem47:6958-63 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reduced folate transporter |
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Name: | Reduced folate transporter |
Synonyms: | FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 64885.16 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469594 |
Residue: | 591 |
Sequence: | MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
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BDBM50158570 |
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n/a |
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Name | BDBM50158570 |
Synonyms: | 2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2,3-dihydro-1-oxo-2(1H)-isoindolyl]glutaric acid | CHEMBL388501 |
Type | Small organic molecule |
Emp. Form. | C20H20N8O5 |
Mol. Mass. | 452.4234 |
SMILES | Nc1nc(N)c2nc(CNc3ccc4C(=O)N(Cc4c3)C(CCC(O)=O)C(O)=O)cnc2n1 |
Structure |
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