| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide N-methyltransferase |
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| Ligand | BDBM50588103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2186336 (CHEMBL5098418) |
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| IC50 | 4780±n/a nM |
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| Citation |  Gao, Y; van Haren, MJ; Buijs, N; Innocenti, P; Zhang, Y; Sartini, D; Campagna, R; Emanuelli, M; Parsons, RB; Jespers, W; Gutiérrez-de-Terán, H; van Westen, GJP; Martin, NI Potent Inhibition of Nicotinamide J Med Chem64:12938-12963 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide N-methyltransferase |
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| Name: | Nicotinamide N-methyltransferase |
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| Synonyms: | NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT) |
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| Type: | Protein |
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| Mol. Mass.: | 29571.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 264 |
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| Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSRPL
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| BDBM50588103 |
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| n/a |
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| Name | BDBM50588103 |
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| Synonyms: | CHEMBL5186494 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N7O3 |
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| Mol. Mass. | 407.4258 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNC\C=C\c2ccc(cc2)C#N)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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