| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
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| Ligand | BDBM50588525 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187294 (CHEMBL5099376) |
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| IC50 | 5.3±n/a nM |
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| Citation |  He, P; Bian, A; Miao, Y; Jin, W; Chen, H; He, J; Li, L; Sun, Y; Ye, J; Liu, M; Yi, Z; Zhou, W; Chen, Y Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment. J Med Chem65:15487-15511 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 3 |
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| Name: | Signal transducer and activator of transcription 3 |
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| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
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| Type: | Protein |
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| Mol. Mass.: | 88064.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P40763 |
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| Residue: | 770 |
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| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
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| BDBM50588525 |
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| n/a |
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| Name | BDBM50588525 |
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| Synonyms: | CHEMBL5177956 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H32F3N7O5 |
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| Mol. Mass. | 699.6784 |
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| SMILES | COc1ccc(cc1)-c1noc(n1)-c1cnc(Oc2ccc3cc(C(=O)N4CCN(Cc5ccc(OCC(F)(F)F)cc5)CC4)n(C)c3c2)cn1 |
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| Structure | 
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