| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50588535 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187421 (CHEMBL5099503) |
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| Kd | 12±n/a nM |
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| Citation |  Sun, Y; Xu, L; Shao, H; Quan, D; Mo, Z; Wang, J; Zhang, W; Yu, J; Zhuang, C; Xu, K Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease. J Med Chem65:14957-14969 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM50588535 |
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| n/a |
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| Name | BDBM50588535 |
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| Synonyms: | CHEMBL5171828 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20F5N3O5S |
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| Mol. Mass. | 593.522 |
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| SMILES | Fc1ccc(Oc2cc3nc(NC(=O)C4CCOC4)sc3cc2F)cc1NC(=O)Cc1cccc(OC(F)(F)F)c1 |
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| Structure | 
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