| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1 |
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| Ligand | BDBM50371232 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2192898 (CHEMBL5105258) |
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| Kd | 20000±n/a nM |
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| Citation |  McCoy, MA; Spicer, D; Wells, N; Hoogewijs, K; Fiedler, M; Baud, MGJ Biophysical Survey of Small-Molecule ?-Catenin Inhibitors: A Cautionary Tale. J Med Chem65:7246-7261 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Catenin beta-1 |
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| Name: | Catenin beta-1 |
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| Synonyms: | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85484.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504364 |
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| Residue: | 781 |
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| Sequence: | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
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| BDBM50371232 |
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| n/a |
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| Name | BDBM50371232 |
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| Synonyms: | CARNOSIC ACID |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28O4 |
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| Mol. Mass. | 332.4339 |
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| SMILES | CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O |r| |
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| Structure | 
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