| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Ligand | BDBM406663 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2193380 (CHEMBL5105740) |
|---|
| IC50 | 110±n/a nM |
|---|
| Citation |  Leit, S; Greenwood, JR; Mondal, S; Carriero, S; Dahlgren, M; Harriman, GC; Kennedy-Smith, JJ; Kapeller, R; Lawson, JP; Romero, DL; Toms, AV; Shelley, M; Wester, RT; Westlin, W; McElwee, JJ; Miao, W; Edmondson, SD; Masse, CE Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett73:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Name: | Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 133666.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29597 |
|---|
| Residue: | 1187 |
|---|
| Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
|
|
|
|---|
| BDBM406663 |
|---|
| n/a |
|---|
| Name | BDBM406663 |
|---|
| Synonyms: | US10336752, Compound 1 | US10336752, Compound 2 | US10336752, Compound 4 | US10336752, Compound 5 | US10336752, Compound 6 | US11040967, Compound 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20F2N4O2 |
|---|
| Mol. Mass. | 434.438 |
|---|
| SMILES | Fc1cccc(F)c1-c1cc(Nc2ccc(cc2)C(=O)N2CCCC2)c2C(=O)NCc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
