| Reaction Details |
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 | Report a problem with these data |
| Target | SRSF protein kinase 1 |
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| Ligand | BDBM221070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2193526 (CHEMBL5105886) |
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| IC50 | <10.0±n/a nM |
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| Citation |  Tang, J; Xie, Y; Huang, J; Zhang, L; Jiang, W; Li, Z; Bian, J A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing. Bioorg Med Chem70:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| SRSF protein kinase 1 |
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| Name: | SRSF protein kinase 1 |
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| Synonyms: | SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1 |
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| Type: | Protein |
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| Mol. Mass.: | 74318.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96SB4 |
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| Residue: | 655 |
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| Sequence: | MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
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| BDBM221070 |
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| n/a |
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| Name | BDBM221070 |
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| Synonyms: | SPHINX | US9695160, SPHINX | US9796707, Reference Compound SPHINX |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17F3N2O3 |
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| Mol. Mass. | 354.3237 |
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| SMILES | Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F |
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| Structure | 
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