Ki Summary

Reaction Details

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Target

Growth hormone secretagogue receptor type 1

Ligand

BDBM50161058

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306206 (CHEMBL830164)

IC50

350±n/a nM

Citation

Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett15:1201-4 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Growth hormone secretagogue receptor type 1

Name:

Growth hormone secretagogue receptor type 1

Synonyms:

Type:

Receptor

Mol. Mass.:

41334.57

Organism:

Homo sapiens (Human)

Description:

Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.

Residue:

366

Sequence:

MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT

BDBM50161058

n/a

Name

BDBM50161058

Synonyms:

3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid {2-[(benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-phenyl}-amide | CHEMBL181584

Type

Small organic molecule

Emp. Form.

C26H19Cl2N3O5

Mol. Mass.

524.352

SMILES

Cc1onc(c1C(=O)Nc1ccccc1C(=O)NCc1ccc2OCOc2c1)-c1c(Cl)cccc1Cl |(-3.38,2.35,;-4.33,1.12,;-5.86,1.2,;-6.42,-.22,;-5.22,-1.19,;-3.93,-.36,;-2.46,-.75,;-2.07,-2.24,;-1.39,.34,;.1,-.03,;.89,-1.35,;2.45,-1.34,;3.2,,;2.41,1.32,;.87,1.3,;.85,2.84,;-.23,3.93,;1.93,3.93,;3.43,4.35,;4.52,3.25,;4.09,1.79,;5.2,.7,;6.7,1.12,;7.99,.27,;9.18,1.26,;8.62,2.7,;7.08,2.59,;5.99,3.68,;-5.13,-2.73,;-3.77,-3.43,;-2.28,-3.83,;-3.67,-4.99,;-4.96,-5.81,;-6.34,-5.1,;-6.42,-3.57,;-7.8,-2.9,)|

Structure