Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Growth hormone secretagogue receptor type 1 | ||
| Ligand | BDBM50161062 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306206 (CHEMBL830164) | ||
| IC50 | 600±n/a nM | ||
| Citation |  Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett15:1201-4 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Growth hormone secretagogue receptor type 1 | |||
| Name: | Growth hormone secretagogue receptor type 1 | ||
| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) | ||
| Type: | Receptor | ||
| Mol. Mass.: | 41334.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. | ||
| Residue: | 366 | ||
| Sequence: |
| ||
| BDBM50161062 | |||
| n/a | |||
| Name | BDBM50161062 | ||
| Synonyms: | 3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-2-ethyl-phenyl)-amide | CHEMBL443560 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H23Cl2N3O3 | ||
| Mol. Mass. | 448.342 | ||
| SMILES | CCN(CC)c1ccc(NC(=O)c2c(C)onc2-c2c(Cl)cccc2Cl)c(OC)c1 |(7.72,-1.64,;6.22,-1.19,;5.88,.3,;7,1.34,;6.64,2.84,;4.39,.74,;3.97,2.23,;2.53,2.63,;1.45,1.55,;-.07,1.95,;-1.13,.86,;-.75,-.63,;-2.61,1.25,;-3.02,2.73,;-2.07,3.93,;-4.55,2.81,;-5.1,1.37,;-3.88,.41,;-3.81,-1.13,;-2.44,-1.83,;-.95,-2.22,;-2.35,-3.39,;-3.68,-4.2,;-5.03,-3.53,;-5.1,-1.99,;-6.48,-1.29,;1.85,.09,;.75,-1,;1.15,-2.49,;3.34,-.31,)| | ||
| Structure | 
| ||