| Reaction Details |
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 | Report a problem with these data |
| Target | Steryl-sulfatase |
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| Ligand | BDBM50161121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302805 (CHEMBL838513) |
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| Ki | 12±n/a nM |
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| Citation |  Lehr, P; Billich, A; Wolff, B; Nussbaumer, P N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase. Bioorg Med Chem Lett15:1235-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steryl-sulfatase |
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| Name: | Steryl-sulfatase |
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| Synonyms: | ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65503.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08842 |
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| Residue: | 583 |
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| Sequence: | MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
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| BDBM50161121 |
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| n/a |
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| Name | BDBM50161121 |
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| Synonyms: | 4-(4-Bromo-2,5-dichloro-thiophene-3-sulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester | CHEMBL178944 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19BrCl2N2O5S2 |
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| Mol. Mass. | 522.262 |
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| SMILES | CC(C)(C)OC(=O)N1CCC(CC1)C(=O)NS(=O)(=O)c1c(Cl)sc(Cl)c1Br |
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| Structure | 
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