| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50589636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2193935 (CHEMBL5106295) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Ginnetti, AT; Paone, DV; Nanda, KK; Li, J; Busuek, M; Johnson, SA; Lu, J; Soisson, SM; Robinson, R; Fisher, J; Webber, A; Wesolowski, G; Ma, B; Duong, L; Carroll, S; Burgey, CS; Stachel, SJ Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis. Bioorg Med Chem Lett74:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50589636 |
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| n/a |
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| Name | BDBM50589636 |
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| Synonyms: | CHEMBL5177683 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F5N5O2 |
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| Mol. Mass. | 519.4665 |
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| SMILES | FC(F)(F)Cn1cc(c(n1)[C@@H]1CCC(F)(F)C[C@H]1C(=O)NC1(CC1)C#N)-c1ccc(cc1)-c1ncco1 |r| |
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| Structure | 
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