Reaction Details |
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Target | Phospholipase A2, membrane associated |
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Ligand | BDBM50055366 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306563 (CHEMBL829138) |
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IC50 | 13±n/a nM |
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Citation | Sawyer, JS; Beight, DW; Smith, EC; Snyder, DW; Chastain, MK; Tielking, RL; Hartley, LW; Carlson, DG Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2. J Med Chem48:893-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phospholipase A2, membrane associated |
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Name: | Phospholipase A2, membrane associated |
Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
Type: | Hydrolase |
Mol. Mass.: | 16101.20 |
Organism: | Homo sapiens (Human) |
Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
Residue: | 144 |
Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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BDBM50055366 |
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n/a |
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Name | BDBM50055366 |
Synonyms: | (3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium |
Type | Small organic molecule |
Emp. Form. | C21H20N2O5 |
Mol. Mass. | 380.3939 |
SMILES | CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1 |
Structure |
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