Ki Summary

Reaction Details

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Target

Liver carboxylesterase 1

Ligand

BDBM50073973

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_305902 (CHEMBL832566)

IC50

5000±n/a nM

Citation

Leung, D; Du, W; Hardouin, C; Cheng, H; Hwang, I; Cravatt, BF; Boger, DL Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorg Med Chem Lett15:1423-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Liver carboxylesterase 1

Name:

Liver carboxylesterase 1

Synonyms:

Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1)

Type:

Protein

Mol. Mass.:

62520.83

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

567

Sequence:

MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL

BDBM50073973

n/a

Name

BDBM50073973

Synonyms:

(E)-1,1,1-Trifluoro-nonadec-10-en-2-one | 1,1,1-Trifluoro-nonadec-10-en-2-one | CHEMBL329187

Type

Small organic molecule

Emp. Form.

C19H33F3O

Mol. Mass.

334.4599

SMILES

CCCCCCCC\C=C\CCCCCCCC(=O)C(F)(F)F

Structure